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2015|16 Annual Report Fraunhofer IGB - MOLECULAR BIOTECHNOLOGY

Contact apl. Prof. Dr. rer. nat. Steffen Rupp Head of Department Phone +49 711 970-4045 steffen.rupp@igb.fraunhofer.deRange of services Screening of targets and drugs for anti-infectives (infec- tion models, cell-based screening assays) Proteome analyses (2D-/LC proteomics) High-throughput sequencing of genomes and transcrip- tomes Next-generation diagnostics of blood samples (circulating nucleic acids in plasma or serum, CNAPS) Development of DNA microarrays: probe design, manufac- turing of arrays, sample preparation procedures Cell-based assays: antiviral assays (GLP), TLR/PRR-based assays/pyrogen detection (GLP), mutagenicity, toxicity Development of production cell lines and processes for recombinant production of proteins (biosimilars, protein purification and characteri ation Cell-free protein synthesis, synthetic biology with non- natural amino acids Development of new high-throughput enzyme assays and screening processes Strain and parameter screening in multi-fermenter systems Development of integrated fermentation processes for industrial biotechnology, including the processing of both raw materials and products Chemical-physical and biochemical analysis Infrastructure and technical equipment Molecular-biological laboratories conforming to safety levels L2, S1 and S2 of the German GenTSV (genetic engineering safety regulations) Microarray facility, universal microarray platform Quantitative real time PCR (qRT-PCR LightCycler 480) High-throughput DNA parallel sequencing facility for nucleic acid analysis (Illumina HiSeq2000, Roche Junior) Proteomics facility using high-resolution MS technologies (2D gel electrophoresis, nano-LC-MALDI-TOF/TOF, HPLC- ESI-MS/MS) Fermentation plant for suspension and adherent cell cultures up to 10 liters of non-GLP Plants for protein purification Multi-fermentation plants for bioprocess development, and fermenters (up to 40 liters), S2/L2 Cell disruption equipment (ball mills, high-pressure autoclave, etc.) GC-MS/MS, LC-MS/MS, IC, ICP-AES, and ICP-MS, accredited by the Deutsche Akkreditierungsstelle GmbH 41 Phone +49711970-4045