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2015|16 Annual Report Fraunhofer IGB

Examination of the culture media during the cell culture used for the formation of the clickECM In the clickECM project, researchers from cell biology and material sciences develop a biocompatible and stable coating for medical implants. It consists of the extracellular matrix (ECM) of primary cells, the natural environment of the cells in the tissue. For this purpose, the researchers culture human cells in a cell culture media which contains a sugar modified with a click function. The cells metabolize the click-functionalized sugars during growth and thus incorporate the click function into the glycan structures of their ECM. When the clickECM is isolated and brought to a material surface equipped with a complementary click function, both connect via stable covalent bonds (see page 60).